Aether Paradise is a very large floating structure that serves as an artificial island located in the middle of the Alola region, near Akala Island. It was created by the Aether Foundation to serve as a base for their research.
To protect the wild Pokémon being treated in the facility, a jamming signal prevents the use of empty Poké Balls throughout the island.
As for Lusamine's Mansion, it has been redone to have multiple apartments inside. One is for the acting director/professor, some allotted for visiting professors, interns, and other on site staff.
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Aether 
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